ATX-304, formerly known as O304, is an investigational small-molecule compound studied for its effects on AMP-activated protein kinase (AMPK), a cellular regulator of energy metabolism. Published research explores its role in energy sensing, mitochondrial respiration, and metabolic signaling.
Solas Science supplies ATX-304 in a 100 mg capsule format, with 60 capsules per bottle and 6,000 mg total content.
For laboratory research use only. Not for human or veterinary use. Not a dietary supplement, food, drug, or cosmetic. Not for diagnostic or therapeutic application.
What Is ATX-304?
ATX-304 is the compound previously reported in the scientific literature as O304. It is described as a pan-AMPK activator, with activity investigated across different cellular AMPK complexes. AMPK is involved in coordinating cellular responses to changes in energy availability.
Early mechanistic experiments reported that O304 increases AMPK activity by limiting dephosphorylation at threonine 172, a site associated with AMPK activation. The compound did not directly allosterically activate AMPK in those experiments. These findings provide a basis for studying energy-sensing pathways in controlled experimental systems.
Scientific Research Areas of ATX-304
AMPK Signaling and Cellular Energy Sensing
Research examines AMPK phosphorylation, downstream acetyl-CoA carboxylase signaling, and cellular responses to metabolic stress.
Mitochondrial Respiration and Substrate Utilization
Experimental work investigates oxygen consumption, mitochondrial uncoupling, and the relationship between glucose uptake and glucose utilization in model systems.
Lipid Metabolism
Preclinical studies examine fatty acid oxidation, lipid synthesis, oxidative stress, and hepatic lipid distribution. These research endpoints do not establish safety or effectiveness for personal use.
Product Specifications
- Compound: ATX-304
- Format: Capsules
- Strength: 100 mg per capsule
- Count: 60 capsules per bottle
- Total content: 6,000 mg per bottle
- Intended use: Laboratory and analytical research only
Quality and Analytical Testing
Review the batch-specific Certificate of Analysis (COA) for the analytical methods and results reported for the tested sample. Analytical findings apply to the sample and lot identified in that report.
Batch Documentation — ATX-403
The supplied ILS Laboratories certificate, dated September 25, 2026, reports the following results for lot ATX-403:
- Reported HPLC purity: 99.22%
- Reported content: 103.73 mg
- Identity (HPLC-RTM): ATX-304 confirmed
- Residual solvents: covered in the batch certificate report
These results apply to the tested sample. The labeled product strength remains 100 mg per capsule. Match the lot on the bottle to the original report and review its methods and limitations.
View the ATX-304 Certificate of Analysis — lot ATX-403 · Browse the COA Portal
Product Information
| Specification | Details |
| Product Name | ATX-304 |
| Brand | Solas Science |
| Literature Name | O304 |
| Quantity | 60 capsules (6,000 mg total) |
| Strength | 100 mg per capsule |
| Format | Capsules |
| Compound Type | Small-molecule research compound |
| Research Area | AMPK signaling and cellular energy metabolism |
| Application | Laboratory and analytical research only |
Handling and Storage
Follow the product label and supplier handling documentation. Keep the container tightly closed and protected from heat, moisture, and direct sunlight. Handle using appropriate laboratory safety practices and personal protective equipment. Keep out of reach of children and unauthorized personnel.
Research References
- Steneberg et al., JCI Insight (2018): O304 and AMPK signaling
- Steneberg et al., Communications Biology (2023): O304 and mitochondrial metabolism
- Holm et al., JCI Insight (2025): ATX-304 in preclinical metabolic research
Research Use Disclaimer
This product is sold strictly for laboratory research use only. It is not intended for human consumption, human ingestion, veterinary use, therapeutic use, diagnostic use, or any in-vivo application in humans or animals. It is not a dietary supplement, food, drug, or cosmetic, and it has not been evaluated by the FDA for safety or efficacy. No statement on this page should be interpreted as a medical claim or as a recommendation for personal use.
By purchasing this product, the buyer confirms they are a qualified researcher or research organization, that they are at least 21 years of age, and that the material will be handled and used only within an appropriate research setting in compliance with all applicable local, state, and federal laws and regulations.
