5-Amino-1MQ | NNMT Pathway Research Compound

5-Amino-1MQ is a small-molecule compound studied for its ability to inhibit nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular nicotinamide and methyl-donor metabolism. NNMT converts nicotinamide into 1-methylnicotinamide, potentially diverting nicotinamide away from the NAD⁺ salvage pathway when NNMT activity is elevated.

By inhibiting NNMT, 5-Amino-1MQ is investigated for its potential to preserve intracellular nicotinamide availability and support NAD⁺ homeostasis. NAD⁺ is an essential coenzyme involved in cellular energy production, redox balance, sirtuin signaling, and normal mitochondrial metabolism.

Preclinical research suggests that NNMT inhibition may influence NAD⁺ availability, lipid metabolism, energy expenditure, and mitochondrial-associated metabolic pathways. These properties make 5-Amino-1MQ a valuable research tool for studying the relationship between NNMT activity, NAD⁺ balance, mitochondrial function, and metabolic flexibility.

Supplied at 50 mg per vial.

For laboratory research use only. Not for human consumption, diagnostic use, or therapeutic use.