Semax is a synthetic heptapeptide derived from the ACTH(4–10) fragment of adrenocorticotropic hormone, modified by replacing the terminal residues with a proline-glycine-proline sequence. The modification removes the parent hormone’s adrenocorticotropic activity while retaining the neuroactive character of the fragment — the reason Semax is studied as a neuropeptide rather than as a hormone analog.
Researchers investigate Semax primarily in connection with neurotrophic signaling. Published preclinical work reports changes in brain-derived neurotrophic factor (BDNF) and nerve growth factor expression, along with broad shifts in gene expression profiles, which has made it a recurring subject in molecular neuroscience.
Solas Science supplies Semax as a research-grade compound in a metered nasal spray format at a labeled 100 mcg per spray, prepared under controlled conditions with quality procedures designed to support consistency, reliability, and analytical reproducibility.
For laboratory research use only. Not for human or veterinary use. Not a dietary supplement, food, drug, or cosmetic. Not for diagnostic or therapeutic application.
What Is Semax?
Semax (CAS 80714-61-0) is the heptapeptide Met-Glu-His-Phe-Pro-Gly-Pro, with the molecular formula C37H51N9O10S and a molecular weight of 813.92 g/mol. The first four residues (MEHF) correspond to ACTH(4–7); the C-terminal Pro-Gly-Pro is a synthetic addition.
That Pro-Gly-Pro tail serves the same purpose as in Selank: it confers resistance to enzymatic degradation, extending the peptide’s working life enough to be studied in intact systems. The two compounds are frequently discussed together in the literature for this reason, despite targeting different pathways.
Mechanistic research most often centers on BDNF and TrkB signaling, with additional work on the peptide’s reported interaction with the melanocortin system, the dopaminergic and serotonergic systems, and on its effect on expression of genes associated with neuronal plasticity and inflammation.
About the Metered Nasal Spray Format
This preparation supplies Semax as an aqueous solution in a 10 mL bottle fitted with a metered pump delivering a labeled 100 mcg per actuation — approximately 100 metered sprays per bottle, or 10 mg of compound in total. Actual spray count varies with pump priming and residual volume.
Semax is among the most commonly studied compounds in the intranasal peptide literature. The original Russian research program developed and characterized it primarily as an intranasal preparation, and a large share of subsequent preclinical work has followed that precedent, which makes this format the closer match to the published record.
Researchers who need to control concentration themselves, or who are working in cell culture and solution-phase assays, may prefer the lyophilized powder presentation, which is reconstituted to a concentration of the investigator’s choosing. This metered format trades that flexibility for a fixed, pre-measured dose delivered without reconstitution.
Scientific Research Areas of Semax
Semax is investigated across molecular neuroscience, neurotrophic signaling, gene-expression research, and peptide pharmacology.
Neurotrophic Factor Signaling
The most active research area concerns growth factor expression. Investigators examine:
- BDNF expression and pro-BDNF processing
- TrkB receptor activation and downstream cascades
- Nerve growth factor levels in tissue and culture models
- Neuronal survival and differentiation endpoints
Gene-Expression and Transcriptomic Research
Microarray and sequencing work uses Semax to study broad transcriptional response:
- Expression profiling in cortical and hippocampal tissue
- Genes associated with neuronal plasticity and synaptogenesis
- Inflammatory and immune-related transcriptional programs
- Time-course of expression changes following exposure
Neuroprotection and Ischemia Models
A large preclinical literature examines Semax under experimental insult, including:
- Cerebral ischemia and reperfusion models
- Oxidative stress and excitotoxicity endpoints
- Inflammatory marker expression in injured tissue
- Functional recovery measures in preclinical paradigms
Behavioral and Cognitive Paradigms
Behavioral research with Semax investigates:
- Learning and memory task performance in rodent models
- Attention and exploratory behavior measures
- Stress-adaptation and anxiety-related endpoints
- Comparison with other ACTH fragment analogs
Product Specifications
- Compound: Semax (ACTH(4–7) analog heptapeptide)
- Format: Metered nasal spray bottle
- Labeled strength: 100 mcg per spray
- Total volume: 10 mL
- Sprays per bottle: Approximately 100
- Total compound content: 10 mg
- Intended use: Laboratory and analytical research applications only
Quality and Analytical Testing
Semax supplied by Solas Science is prepared under controlled conditions and evaluated through quality procedures designed to support purity, consistency, and reliability for laboratory and analytical research applications.
Quality processes may include:
- Raw material assessment
- Compound identity confirmation
- Purity evaluation
- Batch consistency testing
- Fill-volume and concentration verification
- Controlled preparation environments
- Laboratory-grade metered-spray packaging
Analytical documentation for the current lot is available on request.
Product Information
| Specification | Details |
| Product Name | Semax Research Compound |
| Brand | Solasscience |
| Chemical Name | L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-prolylglycyl-L-proline |
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro |
| Molecular Formula | C37H51N9O10S |
| Molecular Weight | 813.92 g/mol |
| CAS Number | 80714-61-0 |
| Format | Metered nasal spray, 10 mL bottle |
| Labeled Strength | 100 mcg per spray |
| Total Content | 10 mg |
| Formulation | Aqueous solution |
| Compound Type | Synthetic heptapeptide, ACTH fragment analog |
| Application | Laboratory and analytical research only |
| Research Area | Neurotrophic signaling and BDNF regulation |
| Quality Standard | Research grade |
Handling and Storage
Store refrigerated at 2–8 °C, protected from light, and do not freeze — freeze-thaw cycling can degrade peptides in solution and damage the metering pump. Keep the bottle upright with the cap fitted, and clearly labeled for laboratory inventory. As an aqueous preparation this product has a shorter working life than a lyophilized powder; record the date the bottle is first opened and handle it accordingly.
Handle in accordance with standard laboratory safety practice, including appropriate personal protective equipment. The metering pump is intended for controlled dispensing in a laboratory setting only. Keep out of reach of children and unauthorized personnel.
Research Use Disclaimer
This product is sold strictly for laboratory research use only. It is not intended for human consumption, human ingestion, intranasal administration to humans or animals, veterinary use, therapeutic use, diagnostic use, or any in-vivo application. It is not a dietary supplement, food, drug, or cosmetic, and it has not been evaluated by the FDA for safety or efficacy. The metered-spray format is a laboratory dispensing convenience and is not a route-of-administration recommendation. No statement on this page should be interpreted as a medical claim or as a recommendation for personal use.
By purchasing this product, the buyer confirms they are a qualified researcher or research organization, that they are at least 21 years of age, and that the material will be handled and used only within an appropriate research setting in compliance with all applicable local, state, and federal laws and regulations.
