Selank is a synthetic heptapeptide analog of tuftsin, the naturally occurring immunoregulatory tetrapeptide, extended with a proline-glycine-proline sequence that substantially increases its stability relative to the parent molecule. It has been investigated in preclinical research for interactions spanning neuroimmune communication, GABAergic signaling, and stress-response biology.
Researchers investigate Selank because it sits at the intersection of two systems usually studied separately: it retains tuftsin’s immunomodulatory character while also showing activity in neurotransmitter-related pathways. That dual profile makes it a useful tool compound for examining how immune and central nervous system signaling interact.
Solas Science supplies Selank as a research-grade compound in a metered nasal spray format at a labeled 100 mcg per spray, prepared under controlled conditions with quality procedures designed to support consistency, reliability, and analytical reproducibility.
For laboratory research use only. Not for human or veterinary use. Not a dietary supplement, food, drug, or cosmetic. Not for diagnostic or therapeutic application.
What Is Selank?
Selank (CAS 129954-34-3) is the heptapeptide Thr-Lys-Pro-Arg-Pro-Gly-Pro, with the molecular formula C33H57N11O9 and a molecular weight of 751.88 g/mol. The first four residues correspond to tuftsin (Thr-Lys-Pro-Arg), a fragment of the immunoglobulin G heavy chain.
The appended Pro-Gly-Pro tail is the design feature that matters experimentally. Tuftsin itself is degraded rapidly by peptidases; the proline-rich extension confers resistance to enzymatic cleavage, giving Selank a working half-life long enough to be studied in intact experimental systems rather than only in isolated preparations.
Published preclinical work reports effects on the expression of GABA receptor subunits and on interleukin and interferon signaling, which is the basis for most current research interest. Selank is generally described in the literature as acting through modulation of existing signaling rather than as a direct receptor agonist.
About the Metered Nasal Spray Format
This preparation supplies Selank as an aqueous solution in a 10 mL bottle fitted with a metered pump delivering a labeled 100 mcg per actuation — approximately 100 metered sprays per bottle, or 10 mg of compound in total. Actual spray count varies with pump priming and residual volume.
Selank is one of the compounds for which the intranasal preparation is the historically documented research format — much of the original Russian experimental literature on the peptide was generated using intranasal delivery rather than injection, which is why this presentation appears so often in replication work.
Researchers who need to control concentration themselves, or who are working in cell culture and solution-phase assays, may prefer the lyophilized powder presentation, which is reconstituted to a concentration of the investigator’s choosing. This metered format trades that flexibility for a fixed, pre-measured dose delivered without reconstitution.
Scientific Research Areas of Selank
Selank is investigated across neuroimmunology, neurotransmitter pharmacology, behavioral science, and peptide stability research.
Neuroimmune Signaling Research
The research application closest to Selank’s tuftsin origin concerns immune-nervous system crosstalk. Investigators examine:
- Interleukin and interferon expression profiles
- Cytokine balance in experimental inflammatory models
- Macrophage and monocyte response in culture
- Communication between peripheral immune signaling and central nervous system pathways
GABAergic Neurotransmission
A substantial body of work examines inhibitory neurotransmission endpoints, including:
- GABAA receptor subunit expression
- GABA binding and uptake dynamics in tissue preparations
- Interaction with benzodiazepine-site pharmacology as a comparison
- Downstream inhibitory tone in electrophysiological models
Behavioral and Stress-Response Models
Because Selank shows an anxiolytic-like profile in preclinical paradigms without the sedation associated with classical anxiolytics, experimental work explores:
- Anxiety-related behavior in standardized rodent paradigms
- Locomotor and sedation endpoints as a separation measure
- Learning and memory task performance under experimental stress
- Monoamine turnover under stress conditions
Peptide Stability and Delivery Research
Selank is also a reference compound in peptide chemistry and formulation work:
- Enzymatic degradation kinetics versus unmodified tuftsin
- Proline-rich sequence design and protease resistance
- Stability of aqueous peptide preparations over time
- Comparative uptake across delivery routes in preclinical models
Product Specifications
- Compound: Selank (tuftsin analog heptapeptide)
- Format: Metered nasal spray bottle
- Labeled strength: 100 mcg per spray
- Total volume: 10 mL
- Sprays per bottle: Approximately 100
- Total compound content: 10 mg
- Intended use: Laboratory and analytical research applications only
Quality and Analytical Testing
Selank supplied by Solas Science is prepared under controlled conditions and evaluated through quality procedures designed to support purity, consistency, and reliability for laboratory and analytical research applications.
Quality processes may include:
- Raw material assessment
- Compound identity confirmation
- Purity evaluation
- Batch consistency testing
- Fill-volume and concentration verification
- Controlled preparation environments
- Laboratory-grade metered-spray packaging
Analytical documentation for the current lot is available on request.
Product Information
| Specification | Details |
| Product Name | Selank Research Compound |
| Brand | Solasscience |
| Chemical Name | L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-L-proline |
| Sequence | Thr-Lys-Pro-Arg-Pro-Gly-Pro |
| Molecular Formula | C33H57N11O9 |
| Molecular Weight | 751.88 g/mol |
| CAS Number | 129954-34-3 |
| Format | Metered nasal spray, 10 mL bottle |
| Labeled Strength | 100 mcg per spray |
| Total Content | 10 mg |
| Formulation | Aqueous solution |
| Compound Type | Synthetic heptapeptide, tuftsin analog |
| Application | Laboratory and analytical research only |
| Research Area | Neuroimmune signaling and GABAergic neurotransmission |
| Quality Standard | Research grade |
Handling and Storage
Store refrigerated at 2–8 °C, protected from light, and do not freeze — freeze-thaw cycling can degrade peptides in solution and damage the metering pump. Keep the bottle upright with the cap fitted, and clearly labeled for laboratory inventory. As an aqueous preparation this product has a shorter working life than a lyophilized powder; record the date the bottle is first opened and handle it accordingly.
Handle in accordance with standard laboratory safety practice, including appropriate personal protective equipment. The metering pump is intended for controlled dispensing in a laboratory setting only. Keep out of reach of children and unauthorized personnel.
Research Use Disclaimer
This product is sold strictly for laboratory research use only. It is not intended for human consumption, human ingestion, intranasal administration to humans or animals, veterinary use, therapeutic use, diagnostic use, or any in-vivo application. It is not a dietary supplement, food, drug, or cosmetic, and it has not been evaluated by the FDA for safety or efficacy. The metered-spray format is a laboratory dispensing convenience and is not a route-of-administration recommendation. No statement on this page should be interpreted as a medical claim or as a recommendation for personal use.
By purchasing this product, the buyer confirms they are a qualified researcher or research organization, that they are at least 21 years of age, and that the material will be handled and used only within an appropriate research setting in compliance with all applicable local, state, and federal laws and regulations.
